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dissertation abstracts, dissertation abstracts international ( dai) or the proquest dissertations and theses dissertation abstracts international ( pqdt) database is a bibliography of american ( and international) dissertations published since 1938 by university microfilms international ( umi) / proquest, ann arbor. umi has had an agitated life and the bibliographical data have often. dissertation abstracts en ligne répertoire des thèses soutenues aux etats- unis depuis 1861 dans le domaine des lettres, sciences humaines et sociales. sujet : humanités au sens large ( philosophie, religion, littérature, éducation, histoire, arts. ) ; tous les sujets pour et. dissertation abstracts, dissertation abstracts international ( dai) or uk the proquest dissertations and theses ( pqdt) database is a bibliography of american ( and international) dissertations published since 1938 by university microfilms international ( umi) / proquest, ann arbor. umi has had an agitated life and the bibliographical data have often shifted owner and name, and therefore appears under. the umi dissertation uk abstracts database as well as other online and web- based book. a number of master' s theses are also indexed, with abstracts since 1988. dissertation abstracts online database, dissertation on distance education. where can you buy resume paper.
online access to citations and abstracts for international dissertations and theses. many databases list dissertation abstracts. professor karen heather vousden, cbe, frs, frse, fmedsci ( born 19 july 1957) is a british medical researcher. she is known for her work on the tumour suppressor protein, p53, and in particular her discovery of the important regulatory role of mdm2, an attractive target for anti- cancer agents. from to, she was the director of the cancer research uk beatson institute in glasgow, uk. the protein p53 is a master regulator of the cell cycle and its mutation/ inactivation is associated with over 50% of cancer cases. mutations in p53 are associated with worse survival rates, resistance to therapies, and other risk factors in breast cancer specifically. p53 is encoded by the tp53 gene and is expressed as several transcripts. in the g- rich portion of intron 3, secondary dna. the 12- pass transmembrane receptors that are orthologous to the drosophila patched protein have a well- established role in developmental morphogenesis that is evolutionarily conserved. consequently, inhibition of the mdm2/ p53 interaction has emerged as a promising new therapeutic strategy for the treatment of cancers retaining wild - type p53. this thesis describes the design, synthesis and evaluation of β- hairpins, 8- ( triazolyl) purines and 2, 5- diketopiperazines as mdm2/ p53.
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